6XS7

Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-D2

6XS7 の概要

• エントリーDOI: 10.2210/pdb6xs7/pdb
• 関連するPDBエントリー: 6XS5
• 分子名称: Vacuolar protein sorting-associated protein 29, 48V-DTY-THR-THR-ILE-TYR-TRP-THR-PRO-LEU-GLY-THR-PHE-PRO-ARG-ILE-ARG, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: vps29, retromer, endosome, protein transport, cyclic peptide, inhibitor, protein transport-inhibitor complex, protein transport/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24014.58

構造登録者

Chen, K.-E.,Guo, Q.,Collins, B.M. (登録日: 2020-07-15, 公開日: 2021-07-14, 最終更新日: 2023-10-18)

• 主引用文献: Chen, K.E.,Guo, Q.,Hill, T.A.,Cui, Y.,Kendall, A.K.,Yang, Z.,Hall, R.J.,Healy, M.D.,Sacharz, J.,Norwood, S.J.,Fonseka, S.,Xie, B.,Reid, R.C.,Leneva, N.,Parton, R.G.,Ghai, R.,Stroud, D.A.,Fairlie, D.P.,Suga, H.,Jackson, L.P.,Teasdale, R.D.,Passioura, T.,Collins, B.M.; De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.; Sci Adv, 7:eabg4007-eabg4007, 2021; PubMed: 34851660; DOI: 10.1126/sciadv.abg4007

実験手法

X-RAY DIFFRACTION (1.58 Å)