6XQT
Room-temperature X-ray Crystal structure of SARS-CoV-2 main protease in complex with Narlaprevir
Summary for 6XQT
Entry DOI | 10.2210/pdb6xqt/pdb |
Descriptor | 3C-like proteinase, (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total) |
Functional Keywords | 3c like proteinase, viral protein, viral protein-hydrolase complex, viral protein/hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 2 |
Total formula weight | 69071.05 |
Authors | Kneller, D.W.,Kovalevsky, A.,Coates, L. (deposition date: 2020-07-10, release date: 2020-07-22, Last modification date: 2023-10-18) |
Primary citation | Kneller, D.W.,Galanie, S.,Phillips, G.,O'Neill, H.M.,Coates, L.,Kovalevsky, A. Malleability of the SARS-CoV-2 3CL M pro Active-Site Cavity Facilitates Binding of Clinical Antivirals. Structure, 28:1313-, 2020 Cited by PubMed: 33152262DOI: 10.1016/j.str.2020.10.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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