6XQS

Room-temperature X-ray Crystal structure of SARS-CoV-2 main protease in complex with Telaprevir

6XQS の概要

• エントリーDOI: 10.2210/pdb6xqs/pdb
• 分子名称: 3C-like proteinase, (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide (3 entities in total)
• 機能のキーワード: 3c like proteinase, viral protein, viral protein-hydrolase complex, viral protein/hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34507.41

構造登録者

Kneller, D.W.,Kovalevsky, A.,Coates, L. (登録日: 2020-07-10, 公開日: 2020-07-22, 最終更新日: 2023-10-18)

• 主引用文献: Kneller, D.W.,Galanie, S.,Phillips, G.,O'Neill, H.M.,Coates, L.,Kovalevsky, A.; Malleability of the SARS-CoV-2 3CL M pro Active-Site Cavity Facilitates Binding of Clinical Antivirals.; Structure, 28:1313-, 2020; PubMed: 33152262; DOI: 10.1016/j.str.2020.10.007

実験手法

X-RAY DIFFRACTION (1.9 Å)