6XQR

OXA-48 bound by Compound 2.2

Summary for 6XQR

• Entry DOI: 10.2210/pdb6xqr/pdb
• Descriptor: Beta-lactamase, [1,1'-biphenyl]-4,4'-disulfonic acid, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, beta-lactamase inhibitor, complex, oxacillinase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 57254.23

Authors

Taylor, D.M.,Hu, L.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2020-07-10, release date: 2021-12-15, Last modification date: 2023-11-15)

• Primary citation: Taylor, D.M.,Anglin, J.,Hu, L.,Wang, L.,Sankaran, B.,Wang, J.,Matzuk, M.M.,Prasad, B.V.V.,Palzkill, T.; Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.; Acs Infect Dis., 7:3345-3354, 2021; PubMed: 34817169; DOI: 10.1021/acsinfecdis.1c00501

Experimental method

X-RAY DIFFRACTION (2.2 Å)