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6XQD

Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution

This is a non-PDB format compatible entry.
Summary for 6XQD
Entry DOI10.2210/pdb6xqd/pdb
Descriptor23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (59 entities in total)
Functional Keywordssarecycline; tetracycline; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; decoding center; acne vulgaris, ribosome
Biological sourceEscherichia coli
More
Total number of polymer chains108
Total formula weight4470354.54
Authors
Batool, Z.,Lomakin, I.B.,Bunick, C.G.,Polikanov, Y.S. (deposition date: 2020-07-09, release date: 2020-08-05, Last modification date: 2023-11-15)
Primary citationBatool, Z.,Lomakin, I.B.,Polikanov, Y.S.,Bunick, C.G.
Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.
Proc.Natl.Acad.Sci.USA, 117:20530-20537, 2020
Cited by
PubMed: 32817463
DOI: 10.1073/pnas.2008671117
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

數據於2024-03-27公開中

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