6XQ2

Human antibody S8V2-37 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2)

6XQ2 の概要

• エントリーDOI: 10.2210/pdb6xq2/pdb
• 分子名称: Hemagglutinin, antibody S8V2-37 heavy chain, antibody S8V2-37 light chain, ... (6 entities in total)
• 機能のキーワード: antibody antigen complex, hemagglutinin, virus, influenza, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Influenza A virus (A/Texas/50/2012(H3N2)); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 164747.86

構造登録者

McCarthy, K.R.,Harrison, S.C. (登録日: 2020-07-09, 公開日: 2021-05-19, 最終更新日: 2023-10-18)

主引用文献

McCarthy, K.R.,Lee, J.,Watanabe, A.,Kuraoka, M.,Robinson-McCarthy, L.R.,Georgiou, G.,Kelsoe, G.,Harrison, S.C.
A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface.
Mbio, 12:e0114421-e0114421, 2021

PubMed Abstract: Novel animal influenza viruses emerge, initiate pandemics, and become endemic seasonal variants that have evolved to escape from prevalent herd immunity. These processes often outpace vaccine-elicited protection. Focusing immune responses on conserved epitopes may impart durable immunity. We describe a focused, protective antibody response, abundant in memory and serum repertoires, to a conserved region at the influenza virus hemagglutinin (HA) head interface. Structures of 11 examples, 8 reported here, from seven human donors demonstrate the convergence of responses on a single epitope. The 11 are genetically diverse, with one class having a common, IGκV1-39, light chain. All of the antibodies bind HAs from multiple serotypes. The lack of apparent genetic restriction and potential for elicitation by more than one serotype may explain their abundance. We define the head interface as a major target of broadly protective antibodies with the potential to influence the outcomes of influenza virus infection. The rapid appearance of mutations in circulating human influenza viruses and selection for escape from herd immunity require prediction of likely variants for an annual updating of influenza vaccines. The identification of human antibodies that recognize conserved surfaces on the influenza virus hemagglutinin (HA) has prompted efforts to design immunogens that might selectively elicit such antibodies. The recent discovery of a widely prevalent antibody response to the conserved interface between two HA "heads" (the globular, receptor-binding domains at the apex of the spike-like trimer) has added a new target for these efforts. We report structures of eight such antibodies, bound with HA heads, and compare them with each other and with three others previously described. Although genetically diverse, they all converge on a common binding site. The analysis here can guide immunogen design for preclinical trials.

PubMed: 34060327
DOI: 10.1128/mBio.01144-21

実験手法

X-RAY DIFFRACTION (3.002 Å)