6XN9

Solution NMR structure of recifin, a cysteine-rich tyrosyl-DNA Phosphodiesterase I modulatory peptide from the marine sponge Axinella sp.

6XN9 の概要

• エントリーDOI: 10.2210/pdb6xn9/pdb
• NMR情報: BMRB: 30767
• 分子名称: Recifin modulatory peptide (1 entity in total)
• 機能のキーワード: cystine-rich peptide, protein knot, tyrosyl-dna phosphodiesterase i inhibitor, marine natural product, toxin
• 由来する生物種: Axinella sp. 1 TF-2017
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4924.44

構造登録者

Schroeder, C.I.,Rosengren, K.J.,O'Keefe, B.R. (登録日: 2020-07-02, 公開日: 2021-02-10)

• 主引用文献: Krumpe, L.R.H.,Wilson, B.A.P.,Marchand, C.,Sunassee, S.N.,Bermingham, A.,Wang, W.,Price, E.,Guszczynski, T.,Kelley, J.A.,Gustafson, K.R.,Pommier, Y.,Rosengren, K.J.,Schroeder, C.I.,O'Keefe, B.R.; Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I.; J.Am.Chem.Soc., 142:21178-21188, 2020; PubMed: 33263997; DOI: 10.1021/jacs.0c10418

実験手法

SOLUTION NMR