6XM3

Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 1

6XM3 の概要

• エントリーDOI: 10.2210/pdb6xm3/pdb
• 関連するPDBエントリー: 6XLU 6XM0
• EMDBエントリー: 22251 22253 22254
• 分子名称: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: sars-cov-2 spike, covid19, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 435823.82

構造登録者

Zhou, T.,Tsybovsky, Y.,Olia, A.,Kwong, P.D. (登録日: 2020-06-29, 公開日: 2020-08-12, 最終更新日: 2021-12-15)

• 主引用文献: Zhou, T.,Tsybovsky, Y.,Gorman, J.,Rapp, M.,Cerutti, G.,Chuang, G.Y.,Katsamba, P.S.,Sampson, J.M.,Schon, A.,Bimela, J.,Boyington, J.C.,Nazzari, A.,Olia, A.S.,Shi, W.,Sastry, M.,Stephens, T.,Stuckey, J.,Teng, I.T.,Wang, P.,Wang, S.,Zhang, B.,Friesner, R.A.,Ho, D.D.,Mascola, J.R.,Shapiro, L.,Kwong, P.D.; Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.; Cell Host Microbe, 28:867-879.e5, 2020; PubMed: 33271067; DOI: 10.1016/j.chom.2020.11.004

実験手法

ELECTRON MICROSCOPY (2.9 Å)