6XK0
Albumin-dexamethasone complex
Summary for 6XK0
| Entry DOI | 10.2210/pdb6xk0/pdb |
| Descriptor | Albumin, DEXAMETHASONE, CITRATE ANION, ... (6 entities in total) |
| Functional Keywords | drug transport, esa, structural genomics, transport protein, psi-biology, new york structural genomics research consortium, nysgrc |
| Biological source | Equus caballus (Horse) |
| Total number of polymer chains | 1 |
| Total formula weight | 66594.02 |
| Authors | Czub, M.P.,Majorek, K.A.,Shabalin, I.G.,Minor, W.,New York Structural Genomics Research Consortium (NYSGRC) (deposition date: 2020-06-24, release date: 2020-07-15, Last modification date: 2023-10-18) |
| Primary citation | Shabalin, I.G.,Czub, M.P.,Majorek, K.A.,Brzezinski, D.,Grabowski, M.,Cooper, D.R.,Panasiuk, M.,Chruszcz, M.,Minor, W. Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy. Iucrj, 7:-, 2020 Cited by PubMed Abstract: Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by binding to serum albumin. Here, the first structure of serum albumin in complex with dexamethasone is reported. Dexamethasone binds to drug site 7, which is also the binding site for commonly used nonsteroidal anti-inflammatory drugs and testosterone, suggesting potentially problematic binding competition. This study bridges structural findings with an analysis of publicly available clinical data from Wuhan and suggests that an adjustment of the dexamethasone regimen should be further investigated as a strategy for patients affected by two major COVID-19 risk factors: low albumin levels and diabetes. PubMed: 33063792DOI: 10.1107/S2052252520012944 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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