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6XJU

Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)

Summary for 6XJU
Entry DOI10.2210/pdb6xju/pdb
DescriptorGTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (7 entities in total)
Functional Keywordsnuclear export, crm1, xpo1, exportin-1, protein transport
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight159196.48
Authors
Baumhardt, J.M.,Chook, Y.M. (deposition date: 2020-06-24, release date: 2021-01-27, Last modification date: 2023-10-18)
Primary citationWalker, J.S.,Hing, Z.A.,Harrington, B.,Baumhardt, J.,Ozer, H.G.,Lehman, A.,Giacopelli, B.,Beaver, L.,Williams, K.,Skinner, J.N.,Cempre, C.B.,Sun, Q.,Shacham, S.,Stromberg, B.R.,Summers, M.K.,Abruzzo, L.V.,Rassenti, L.,Kipps, T.J.,Parikh, S.,Kay, N.E.,Rogers, K.A.,Woyach, J.A.,Coppola, V.,Chook, Y.M.,Oakes, C.,Byrd, J.C.,Lapalombella, R.
Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14:17-17, 2021
Cited by
PubMed: 33451349
DOI: 10.1186/s13045-021-01032-2
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.193 Å)
Structure validation

220472

數據於2024-05-29公開中

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