6XJT
Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ)
Summary for 6XJT
Entry DOI | 10.2210/pdb6xjt/pdb |
Descriptor | GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (6 entities in total) |
Functional Keywords | nuclear export, crm1, xpo1, exportin-1, protein transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 159196.41 |
Authors | Baumhardt, J.M.,Chook, Y.M. (deposition date: 2020-06-24, release date: 2021-01-27, Last modification date: 2023-10-18) |
Primary citation | Walker, J.S.,Hing, Z.A.,Harrington, B.,Baumhardt, J.,Ozer, H.G.,Lehman, A.,Giacopelli, B.,Beaver, L.,Williams, K.,Skinner, J.N.,Cempre, C.B.,Sun, Q.,Shacham, S.,Stromberg, B.R.,Summers, M.K.,Abruzzo, L.V.,Rassenti, L.,Kipps, T.J.,Parikh, S.,Kay, N.E.,Rogers, K.A.,Woyach, J.A.,Coppola, V.,Chook, Y.M.,Oakes, C.,Byrd, J.C.,Lapalombella, R. Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14:17-17, 2021 Cited by PubMed: 33451349DOI: 10.1186/s13045-021-01032-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.406 Å) |
Structure validation
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