6XJT

Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ)

6XJT の概要

• エントリーDOI: 10.2210/pdb6xjt/pdb
• 分子名称: GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (6 entities in total)
• 機能のキーワード: nuclear export, crm1, xpo1, exportin-1, protein transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 159196.41

構造登録者

Baumhardt, J.M.,Chook, Y.M. (登録日: 2020-06-24, 公開日: 2021-01-27, 最終更新日: 2023-10-18)

• 主引用文献: Walker, J.S.,Hing, Z.A.,Harrington, B.,Baumhardt, J.,Ozer, H.G.,Lehman, A.,Giacopelli, B.,Beaver, L.,Williams, K.,Skinner, J.N.,Cempre, C.B.,Sun, Q.,Shacham, S.,Stromberg, B.R.,Summers, M.K.,Abruzzo, L.V.,Rassenti, L.,Kipps, T.J.,Parikh, S.,Kay, N.E.,Rogers, K.A.,Woyach, J.A.,Coppola, V.,Chook, Y.M.,Oakes, C.,Byrd, J.C.,Lapalombella, R.; Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.; J Hematol Oncol, 14:17-17, 2021; PubMed: 33451349; DOI: 10.1186/s13045-021-01032-2

実験手法

X-RAY DIFFRACTION (2.406 Å)