6XIF
PCSK9(deltaCRD) in complex with cyclic peptide 83
Summary for 6XIF
Entry DOI | 10.2210/pdb6xif/pdb |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Peptide 83, GLYCEROL, ... (5 entities in total) |
Functional Keywords | protein-peptide complex, cyclic peptide, non-natural amino acids, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 48071.09 |
Authors | Orth, P. (deposition date: 2020-06-19, release date: 2020-11-18, Last modification date: 2024-07-10) |
Primary citation | Alleyne, C.,Amin, R.P.,Bhatt, B.,Bianchi, E.,Blain, J.C.,Boyer, N.,Branca, D.,Embrey, M.W.,Ha, S.N.,Jette, K.,Johns, D.G.,Kerekes, A.D.,Koeplinger, K.A.,LaPlaca, D.,Li, N.,Murphy, B.,Orth, P.,Ricardo, A.,Salowe, S.,Seyb, K.,Shahripour, A.,Stringer, J.R.,Sun, Y.,Tracy, R.,Wu, C.,Xiong, Y.,Youm, H.,Zokian, H.J.,Tucker, T.J. Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63:13796-13824, 2020 Cited by PubMed: 33170686DOI: 10.1021/acs.jmedchem.0c01084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.774 Å) |
Structure validation
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