6XH3
Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.3
6XH3 の概要
エントリーDOI | 10.2210/pdb6xh3/pdb |
分子名称 | TAR BINDING PROTEIN TBP 6.3, TRANS-ACTIVATION RESPONSE ELEMENT (3 entities in total) |
機能のキーワード | protein-rna complex, tar rna, lab-evolved protein, arginine fork, beta hairpin, major-groove readout, base triple, u1a, hiv-1, trans- activation, rna recognition motif, rrm, rna binding protein-rna complex, rna binding protein, rna binding protein/rna |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 18886.07 |
構造登録者 | |
主引用文献 | Chavali, S.S.,Mali, S.M.,Jenkins, J.L.,Fasan, R.,Wedekind, J.E. Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors. J.Biol.Chem., 295:16470-16486, 2020 Cited by PubMed: 33051202DOI: 10.1074/jbc.RA120.015444 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.353 Å) |
構造検証レポート
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