6XET

Tubulin-RB3_SLD in complex with compound 60c

6XET の概要

• エントリーDOI: 10.2210/pdb6xet/pdb
• 分子名称: Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total)
• 機能のキーワード: microtubule inhibitor, colchicine, cell cycle, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 214828.70

構造登録者

White, S.W.,Yun, M. (登録日: 2020-06-13, 公開日: 2021-08-25, 最終更新日: 2023-10-18)

• 主引用文献: Chen, H.,Deng, S.,Albadari, N.,Yun, M.K.,Zhang, S.,Li, Y.,Ma, D.,Parke, D.N.,Yang, L.,Seagroves, T.N.,White, S.W.,Miller, D.D.,Li, W.; Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.; J.Med.Chem., 64:12049-12074, 2021; PubMed: 34378386; DOI: 10.1021/acs.jmedchem.1c00715

実験手法

X-RAY DIFFRACTION (2.6 Å)