6XE7

Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 2-((2-formyl-3-hydroxyphenoxy)methyl)nicotinate

6XE7 の概要

• エントリーDOI: 10.2210/pdb6xe7/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
• 機能のキーワード: hemoglobin, antisickling, aromatic aldehyde, allosteric effector, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65205.66

構造登録者

Pagare, P.P.,Safo, M.K.,Musayev, F.N. (登録日: 2020-06-12, 公開日: 2020-12-02, 最終更新日: 2023-10-18)

• 主引用文献: Pagare, P.P.,Ghatge, M.S.,Chen, Q.,Musayev, F.N.,Venitz, J.,Abdulmalik, O.,Zhang, Y.,Safo, M.K.; Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents.; J.Med.Chem., 63:14724-14739, 2020; PubMed: 33205981; DOI: 10.1021/acs.jmedchem.0c01287

実験手法

X-RAY DIFFRACTION (2 Å)