6XDM

STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH AN ARYL KETONE INHIBITOR

6XDM の概要

• エントリーDOI: 10.2210/pdb6xdm/pdb
• 分子名称: Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 132740.70

構造登録者

Klein, D.J.,Liu, J. (登録日: 2020-06-11, 公開日: 2020-07-29, 最終更新日: 2024-03-06)

• 主引用文献: Liu, J.,Kelly, J.,Yu, W.,Clausen, D.,Yu, Y.,Kim, H.,Duffy, J.L.,Chung, C.C.,Myers, R.W.,Carroll, S.,Klein, D.J.,Fells, J.,Holloway, M.K.,Wu, J.,Wu, G.,Howell, B.J.,Barnard, R.J.O.,Kozlowski, J.A.; Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.; Acs Med.Chem.Lett., 11:1476-1483, 2020; PubMed: 32676157; DOI: 10.1021/acsmedchemlett.0c00302

実験手法

X-RAY DIFFRACTION (1.56 Å)