6XD9

Carbonmonoxy hemoglobin in complex with the antisickling agent 2-hydroxy-6-((6-(hydroxymethyl)pyridin-2-yl)methoxy)benzaldehyde (VZHE039)

6XD9 の概要

• エントリーDOI: 10.2210/pdb6xd9/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
• 機能のキーワード: hemoglobin, aromatic aldehyde, antisickling, allosteric effector, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65149.64

構造登録者

Pagare, P.P.,Safo, M.K.,Musayev, F.N. (登録日: 2020-06-10, 公開日: 2020-12-23, 最終更新日: 2023-10-18)

• 主引用文献: Abdulmalik, O.,Pagare, P.P.,Huang, B.,Xu, G.G.,Ghatge, M.S.,Xu, X.,Chen, Q.,Anabaraonye, N.,Musayev, F.N.,Omar, A.M.,Venitz, J.,Zhang, Y.,Safo, M.K.; VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions.; Sci Rep, 10:20277-20277, 2020; PubMed: 33219275; DOI: 10.1038/s41598-020-77171-2

実験手法

X-RAY DIFFRACTION (2.1 Å)