6XBI

Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW248

6XBI の概要

• エントリーDOI: 10.2210/pdb6xbi/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002394
• 分子名称: 3C-like proteinase, inhibitor UAW248, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: covid, covid19, covid-19, sars, sars cov2, cov, ncov 19, coronavirus, main protease, 3cl, mpro, pro, viral protein, gc376, calpain inhibitor ii, leupeptin, calpain, aldehyde, gc-376, 3cl-like, a-ketoamide, uaw41, uaw246, uaw247, uaw248, 246, 247, 248, alpheketoamide, alpha, ketoamide, peptidomimetic, protease, cysteine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69650.50

構造登録者

Sacco, M.,Ma, C.,Wang, J.,Chen, Y. (登録日: 2020-06-06, 公開日: 2020-06-17, 最終更新日: 2023-11-15)

• 主引用文献: Sacco, M.D.,Ma, C.,Lagarias, P.,Gao, A.,Townsend, J.A.,Meng, X.,Dube, P.,Zhang, X.,Hu, Y.,Kitamura, N.,Hurst, B.,Tarbet, B.,Marty, M.T.,Kolocouris, A.,Xiang, Y.,Chen, Y.,Wang, J.; Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L.; Sci Adv, 6:-, 2020; PubMed: 33158912; DOI: 10.1126/sciadv.abe0751

実験手法

X-RAY DIFFRACTION (1.7 Å)