6XBG
Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW246
Summary for 6XBG
Entry DOI | 10.2210/pdb6xbg/pdb |
Related PRD ID | PRD_002392 |
Descriptor | 3C-like proteinase, inhibitor UAW246, GLYCEROL, ... (5 entities in total) |
Functional Keywords | covid, covid19, covid-19, sars, sars cov2, cov, ncov 19, coronavirus, main protease, 3cl, mpro, pro, viral protein, gc376, calpain inhibitor ii, leupeptin, calpain, aldehyde, gc-376, 3cl-like, a-ketoamide, uaw41, uaw246, uaw247, uaw248, 246, 247, 248, alpheketoamide, alpha, ketoamide, peptidomimetic, protease, cysteine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 4 |
Total formula weight | 69466.20 |
Authors | |
Primary citation | Sacco, M.D.,Ma, C.,Lagarias, P.,Gao, A.,Townsend, J.A.,Meng, X.,Dube, P.,Zhang, X.,Hu, Y.,Kitamura, N.,Hurst, B.,Tarbet, B.,Marty, M.T.,Kolocouris, A.,Xiang, Y.,Chen, Y.,Wang, J. Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6:-, 2020 Cited by PubMed: 33158912DOI: 10.1126/sciadv.abe0751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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