6XB1

Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design

6XB1 の概要

• エントリーDOI: 10.2210/pdb6xb1/pdb
• 分子名称: 3C-like proteinase, 1-ETHYL-PYRROLIDINE-2,5-DIONE (3 entities in total)
• 機能のキーワード: main protease sars-cov-2 3cl mpro, viral protein, hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33984.68

構造登録者

Kneller, D.W.,Kovalevsky, A.,Coates, L. (登録日: 2020-06-05, 公開日: 2020-06-17, 最終更新日: 2023-10-18)

• 主引用文献: Kneller, D.W.,Phillips, G.,O'Neill, H.M.,Tan, K.,Joachimiak, A.,Coates, L.,Kovalevsky, A.; Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.; Iucrj, 7:-, 2020; PubMed: 33063790; DOI: 10.1107/S2052252520012634

実験手法

X-RAY DIFFRACTION (1.8 Å)