6X8G

Crystal structure of TYK2 with Compound 22

6X8G の概要

• エントリーDOI: 10.2210/pdb6x8g/pdb
• 分子名称: Non-receptor tyrosine-protein kinase TYK2, trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}cyclobutane-1-carbonitrile (3 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36933.98

構造登録者

Vajdos, F.F.,Knafels, J.D. (登録日: 2020-06-01, 公開日: 2020-11-25, 最終更新日: 2023-11-15)

• 主引用文献: Gerstenberger, B.S.,Ambler, C.,Arnold, E.P.,Banker, M.E.,Brown, M.F.,Clark, J.D.,Dermenci, A.,Dowty, M.E.,Fensome, A.,Fish, S.,Hayward, M.M.,Hegen, M.,Hollingshead, B.D.,Knafels, J.D.,Lin, D.W.,Lin, T.H.,Owen, D.R.,Saiah, E.,Sharma, R.,Vajdos, F.F.,Xing, L.,Yang, X.,Yang, X.,Wright, S.W.; Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.; J.Med.Chem., 63:13561-13577, 2020; PubMed: 32787094; DOI: 10.1021/acs.jmedchem.0c00948

実験手法

X-RAY DIFFRACTION (2.21 Å)