6X7P

LnmK in complex with 2-sulfonate-propionyl-oxa(dethia)-CoA

6X7P の概要

• エントリーDOI: 10.2210/pdb6x7p/pdb
• 分子名称: Conserved hypthetical protein, (2~{R})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid, (2~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid, ... (5 entities in total)
• 機能のキーワード: transferase, lyase, inhibitor, isostere, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Streptomyces atroolivaceus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37635.89

構造登録者

Stunkard, L.M.,Kick, B.J.,Lohman, J.R. (登録日: 2020-05-30, 公開日: 2020-06-10, 最終更新日: 2023-10-18)

• 主引用文献: Stunkard, L.M.,Kick, B.J.,Lohman, J.R.; Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity.; Biochemistry, 60:365-372, 2021; PubMed: 33482062; DOI: 10.1021/acs.biochem.0c00893

実験手法

X-RAY DIFFRACTION (1.55 Å)