6X5Y
IDO1 in complex with compound 4
Summary for 6X5Y
Entry DOI | 10.2210/pdb6x5y/pdb |
Descriptor | Indoleamine 2,3-dioxygenase 1, 4-fluoro-N-{1-[5-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydro-1,5-naphthyridin-2-yl]cyclopropyl}benzamide (3 entities in total) |
Functional Keywords | indoleamine dioxygenase, ido1, inhibitor complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 89517.11 |
Authors | Lesburg, C.A.,Lammens, A. (deposition date: 2020-05-27, release date: 2021-06-02, Last modification date: 2024-04-03) |
Primary citation | Hopkins, B.,Zhang, H.,Bharathan, I.,Li, D.,Pu, Q.,Zhou, H.,Martinot, T.,Fradera, X.,Lammens, A.,Lesburg, C.A.,Ballard, J.,Knemeyer, I.,Otte, K.,Solban, N.,Vincent, S.,Miller, J.R.,Cheng, M.,Geda, P.,Smotrov, N.,Song, X.,Spacciapoli, P.,Bennett, D.J.,Han, Y. Utilization of MetID and Structural Data to Guide Placement of Spiro and Fused Cyclopropyl Groups for the Synthesis of Low Dose IDO1 Inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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