6X5Y
IDO1 in complex with compound 4
6X5Y の概要
エントリーDOI | 10.2210/pdb6x5y/pdb |
分子名称 | Indoleamine 2,3-dioxygenase 1, 4-fluoro-N-{1-[5-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydro-1,5-naphthyridin-2-yl]cyclopropyl}benzamide (3 entities in total) |
機能のキーワード | indoleamine dioxygenase, ido1, inhibitor complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 89517.11 |
構造登録者 | |
主引用文献 | Hopkins, B.,Zhang, H.,Bharathan, I.,Li, D.,Pu, Q.,Zhou, H.,Martinot, T.,Fradera, X.,Lammens, A.,Lesburg, C.A.,Ballard, J.,Knemeyer, I.,Otte, K.,Solban, N.,Vincent, S.,Miller, J.R.,Cheng, M.,Geda, P.,Smotrov, N.,Song, X.,Spacciapoli, P.,Bennett, D.J.,Han, Y. Utilization of MetID and Structural Data to Guide Placement of Spiro and Fused Cyclopropyl Groups for the Synthesis of Low Dose IDO1 Inhibitors To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.65 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード