6X4H

Sortilin-Progranulin Interaction With Compound 24

6X4H の概要

• エントリーDOI: 10.2210/pdb6x4h/pdb
• 分子名称: Sortilin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-methyl-N-(6-phenoxypyridine-3-carbonyl)-L-leucine, ... (5 entities in total)
• 機能のキーワード: protein protein interaction, unknown function
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75538.42

構造登録者

Parthasarathy, G.,Soisson, S.M.,Klein, D. (登録日: 2020-05-22, 公開日: 2020-08-12, 最終更新日: 2023-10-18)

• 主引用文献: Stachel, S.J.,Ginnetti, A.T.,Johnson, S.A.,Cramer, P.,Wang, Y.,Bukhtiyarova, M.,Krosky, D.,Stump, C.,Hurzy, D.M.,Schlegel, K.A.,Cooke, A.J.,Allen, S.,O'Donnell, G.,Ziebell, M.,Parthasarathy, G.,Getty, K.L.,Ho, T.,Ou, Y.,Jovanovska, A.,Carroll, S.S.,Pausch, M.,Lumb, K.,Mosser, S.D.,Voleti, B.,Klein, D.J.,Soisson, S.M.,Zerbinatti, C.,Coleman, P.J.; Identification of potent inhibitors of the sortilin-progranulin interaction.; Bioorg.Med.Chem.Lett., 30:127403-127403, 2020; PubMed: 32738972; DOI: 10.1016/j.bmcl.2020.127403

実験手法

X-RAY DIFFRACTION (2.9 Å)