6X4A
Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor
6X4A の概要
エントリーDOI | 10.2210/pdb6x4a/pdb |
分子名称 | Reverse transcriptase/ribonuclease H, p51 RT, 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile, ... (5 entities in total) |
機能のキーワード | polymerase, reverse transcriptase, non-nucleoside inhibitor, transferase, hydrolase-inhibitor complex, hydrolase/inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 group M subtype B 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114608.69 |
構造登録者 | Chan, A.H.,Duong, V.N.,Ippolito, J.A.,Jorgensen, W.L.,Anderson, K.S. (登録日: 2020-05-22, 公開日: 2020-07-22, 最終更新日: 2023-10-18) |
主引用文献 | Duong, V.N.,Ippolito, J.A.,Chan, A.H.,Lee, W.G.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29:1902-1910, 2020 Cited by PubMed: 32643196DOI: 10.1002/pro.3910 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.537 Å) |
構造検証レポート
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