6X3S
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide
Summary for 6X3S
Entry DOI | 10.2210/pdb6x3s/pdb |
EMDB information | 22031 |
Descriptor | Gamma-aminobutyric acid receptor subunit beta-2, (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, alpha-D-mannopyranose, ... (11 entities in total) |
Functional Keywords | ion channel, cys-loop receptor, pentametic ligand gated channel, gabaa receptor, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 9 |
Total formula weight | 364815.10 |
Authors | Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh, R.M.,Lindahl, E.,Hibbs, R.E. (deposition date: 2020-05-21, release date: 2020-09-09, Last modification date: 2020-09-23) |
Primary citation | Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh Jr., R.M.,Lindahl, E.,Hibbs, R.E. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585:303-308, 2020 Cited by PubMed: 32879488DOI: 10.1038/s41586-020-2654-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.12 Å) |
Structure validation
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