6X3S

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide

Summary for 6X3S

• Entry DOI: 10.2210/pdb6x3s/pdb
• EMDB information: 22031
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-2, (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, alpha-D-mannopyranose, ... (11 entities in total)
• Functional Keywords: ion channel, cys-loop receptor, pentametic ligand gated channel, gabaa receptor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 9
• Total formula weight: 364815.10

Authors

Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh, R.M.,Lindahl, E.,Hibbs, R.E. (deposition date: 2020-05-21, release date: 2020-09-09, Last modification date: 2020-09-23)

• Primary citation: Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh Jr., R.M.,Lindahl, E.,Hibbs, R.E.; Shared structural mechanisms of general anaesthetics and benzodiazepines.; Nature, 585:303-308, 2020; PubMed: 32879488; DOI: 10.1038/s41586-020-2654-5

Experimental method

ELECTRON MICROSCOPY (3.12 Å)