6X3S

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide

6X3S の概要

• エントリーDOI: 10.2210/pdb6x3s/pdb
• EMDBエントリー: 22031
• 分子名称: Gamma-aminobutyric acid receptor subunit beta-2, (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, alpha-D-mannopyranose, ... (11 entities in total)
• 機能のキーワード: ion channel, cys-loop receptor, pentametic ligand gated channel, gabaa receptor, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 364815.10

構造登録者

Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh, R.M.,Lindahl, E.,Hibbs, R.E. (登録日: 2020-05-21, 公開日: 2020-09-09, 最終更新日: 2020-09-23)

• 主引用文献: Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh Jr., R.M.,Lindahl, E.,Hibbs, R.E.; Shared structural mechanisms of general anaesthetics and benzodiazepines.; Nature, 585:303-308, 2020; PubMed: 32879488; DOI: 10.1038/s41586-020-2654-5

実験手法