6WY0
CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-40 A.K.A 7-[(1R)-1-phenyl-3-{[(1r,4r)-4-phenylcyclohexyl]amino}propyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
6WY0 の概要
エントリーDOI | 10.2210/pdb6wy0/pdb |
分子名称 | Myeloperoxidase light chain, Myeloperoxidase heavy chain, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
機能のキーワード | myeloperoxidase, mpo, heme, oxidoreductase |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 272210.84 |
構造登録者 | |
主引用文献 | Shaw, S.A.,Vokits, B.P.,Dilger, A.K.,Viet, A.,Clark, C.G.,Abell, L.M.,Locke, G.A.,Duke, G.,Kopcho, L.M.,Dongre, A.,Gao, J.,Krishnakumar, A.,Jusuf, S.,Khan, J.,Spronk, S.A.,Basso, M.D.,Zhao, L.,Cantor, G.H.,Onorato, J.M.,Wexler, R.R.,Duclos, F.,Kick, E.K. Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase. Bioorg.Med.Chem., 28:115723-115723, 2020 Cited by PubMed: 33007547DOI: 10.1016/j.bmc.2020.115723 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.799 Å) |
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