6WTJ

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

6WTJ の概要

• エントリーDOI: 10.2210/pdb6wtj/pdb
• 分子名称: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
• 機能のキーワード: covid-19, sars-cov-2, 3clpro, coronavirus, main protease, kinetics, sars, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34311.10

構造登録者

Khan, M.B.,Arutyunova, E.,Young, H.S.,Lemieux, M.J. (登録日: 2020-05-02, 公開日: 2020-05-20, 最終更新日: 2023-10-18)

• 主引用文献: Vuong, W.,Khan, M.B.,Fischer, C.,Arutyunova, E.,Lamer, T.,Shields, J.,Saffran, H.A.,McKay, R.T.,van Belkum, M.J.,Joyce, M.A.,Young, H.S.,Tyrrell, D.L.,Vederas, J.C.,Lemieux, M.J.; Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.; Nat Commun, 11:4282-4282, 2020; PubMed: 32855413; DOI: 10.1038/s41467-020-18096-2

実験手法

X-RAY DIFFRACTION (1.9 Å)