6WSB

Crystal structure of a betaine aldehyde dehydrogenase from Burkholderia pseudomallei bound to cofactor NAD

6WSB の概要

• エントリーDOI: 10.2210/pdb6wsb/pdb
• 分子名称: NAD/NADP-dependent betaine aldehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: national institute of allergy and infectious diseases, niaid, structural genomics, melioidosis, glycine metabolism, serine metabolism, threonine metabolism, covalently bound cofactor, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase
• 由来する生物種: Burkholderia pseudomallei (strain 1710b)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107776.96

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2020-04-30, 公開日: 2020-05-20, 最終更新日: 2024-12-25)

主引用文献

Beard, D.K.,Subramanian, S.,Abendroth, J.,Dranow, D.M.,Edwards, T.E.,Myler, P.J.,Asojo, O.A.
Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.
Acta Crystallogr.,Sect.F, 78:45-51, 2022

PubMed Abstract: Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.

PubMed: 35102892
DOI: 10.1107/S2053230X21013455

実験手法

X-RAY DIFFRACTION (1.55 Å)