6WS0

Rational drug design of phenazopyridine derivatives as novel inhibitors of Rev1-CT

これはPDB形式変換不可エントリーです。

6WS0 の概要

• エントリーDOI: 10.2210/pdb6ws0/pdb
• 分子名称: DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, DNA polymerase zeta catalytic subunit, ... (4 entities in total)
• 機能のキーワード: scaffold, translesion synethesis, dna damage response, dna damage tolerance, protein binding-transferase complex, protein binding/transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42745.22

構造登録者

McPherson, K.S.,Korzhnev, D.M. (登録日: 2020-04-30, 公開日: 2020-12-23, 最終更新日: 2023-10-18)

• 主引用文献: McPherson, K.S.,Zaino, A.M.,Dash, R.C.,Rizzo, A.A.,Li, Y.,Hao, B.,Bezsonova, I.,Hadden, M.K.,Korzhnev, D.M.; Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis.; Chemmedchem, 16:1126-1132, 2021; PubMed: 33314657; DOI: 10.1002/cmdc.202000893

実験手法

X-RAY DIFFRACTION (2.24 Å)