6WR0
Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog
Summary for 6WR0
Entry DOI | 10.2210/pdb6wr0/pdb |
Descriptor | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one, ... (5 entities in total) |
Functional Keywords | cytochrome p450, p450, 17a1, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 226922.84 |
Authors | Petrunak, E.M.,Bart, A.G.,Scott, E.E. (deposition date: 2020-04-29, release date: 2021-05-05, Last modification date: 2023-10-18) |
Primary citation | Petrunak, E.M.,Bart, A.G.,Peng, H.M.,Auchus, R.J.,Scott, E.E. Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299:102999-102999, 2023 Cited by PubMed: 36773804DOI: 10.1016/j.jbc.2023.102999 PDB entries with the same primary citation |
Experimental method |
Structure validation
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