6WQU

CSL (RBPJ) bound to Notch3 RAM and DNA

6WQU の概要

• エントリーDOI: 10.2210/pdb6wqu/pdb
• 分子名称: DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), Recombining binding protein suppressor of hairless, ... (5 entities in total)
• 機能のキーワード: notch signaling, dna binding protein, transcription factor, activation complex, transcription, transcription-signaling protein-dna complex, transcription/signaling protein/dna
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 59357.24

構造登録者

Kovall, R.A.,Gagliani, E.,Hall, D. (登録日: 2020-04-29, 公開日: 2021-03-31, 最終更新日: 2023-10-18)

• 主引用文献: Landor, S.K.J.,Santio, N.M.,Eccleshall, W.B.,Paramonov, V.M.,Gagliani, E.K.,Hall, D.,Jin, S.B.,Dahlstrom, K.M.,Salminen, T.A.,Rivero-Muller, A.,Lendahl, U.,Kovall, R.A.,Koskinen, P.J.,Sahlgren, C.; PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion.; J.Biol.Chem., 296:100593-100593, 2021; PubMed: 33775697; DOI: 10.1016/j.jbc.2021.100593

実験手法

X-RAY DIFFRACTION (2.41 Å)