6WPQ

GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant

Summary for 6WPQ

Entry DOI	10.2210/pdb6wpq/pdb
Descriptor	Heterogeneous nuclear ribonucleoprotein A2 (2 entities in total)
Functional Keywords	amyloidogenic segment, amyloid-like fibril, disease related, multisystem proteinopathy (msp), protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	712.75
Authors	Lu, J.,Cao, Q.,Hughes, M.P.,Sawaya, M.R.,Boyer, D.R.,Cascio, D.,Eisenberg, D.S. (deposition date: 2020-04-27, release date: 2020-08-19, Last modification date: 2024-03-06)
Primary citation	Lu, J.,Cao, Q.,Hughes, M.P.,Sawaya, M.R.,Boyer, D.R.,Cascio, D.,Eisenberg, D.S. CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11:4090-4090, 2020 Cited by PubMed: 32796831 DOI: 10.1038/s41467-020-17905-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation