6WPQ

GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant

6WPQ の概要

• エントリーDOI: 10.2210/pdb6wpq/pdb
• 分子名称: Heterogeneous nuclear ribonucleoprotein A2 (2 entities in total)
• 機能のキーワード: amyloidogenic segment, amyloid-like fibril, disease related, multisystem proteinopathy (msp), protein fibril
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 712.75

構造登録者

Lu, J.,Cao, Q.,Hughes, M.P.,Sawaya, M.R.,Boyer, D.R.,Cascio, D.,Eisenberg, D.S. (登録日: 2020-04-27, 公開日: 2020-08-19, 最終更新日: 2024-03-06)

• 主引用文献: Lu, J.,Cao, Q.,Hughes, M.P.,Sawaya, M.R.,Boyer, D.R.,Cascio, D.,Eisenberg, D.S.; CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.; Nat Commun, 11:4090-4090, 2020; PubMed: 32796831; DOI: 10.1038/s41467-020-17905-y

実験手法

X-RAY DIFFRACTION (1.1 Å)