6WIA

CRYSTAL STRUCTURE OF HUMAN PROTECTIVE PROTEIN/CATHEPSIN A, DFP-INHIBITED (AGED)

Summary for 6WIA

• Entry DOI: 10.2210/pdb6wia/pdb
• Descriptor: Lysosomal protective protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... (6 entities in total)
• Functional Keywords: lysosomal, cathepsin a, cata, ctsa, organophosphate, renin-angiotensin system (ras), hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 54317.49

Authors

Compton, J.R.,Legler, P.M. (deposition date: 2020-04-09, release date: 2020-04-29, Last modification date: 2023-10-18)

• Primary citation: Bouknight, K.D.,Jurkouich, K.M.,Compton, J.R.,Khavrutskii, I.V.,Guelta, M.A.,Harvey, S.P.,Legler, P.M.; Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A.; Biochem. Pharmacol., 177:113980-113980, 2020; PubMed: 32305437; DOI: 10.1016/j.bcp.2020.113980

Experimental method

X-RAY DIFFRACTION (2.21 Å)