6WHQ
Histone deacetylases complex with peptide macrocycles
Summary for 6WHQ
Entry DOI | 10.2210/pdb6whq/pdb |
Descriptor | Histone deacetylase 2, U2M-ASN-PRO-GLU-GLN-DLY-TRP-GLY peptide macrocycle, ZINC ION, ... (8 entities in total) |
Functional Keywords | anchor extension, de novo design macrocycles, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 136620.28 |
Authors | Bera, A.K.,Hosseinzadeh, P.,Watson, P.,Baker, D. (deposition date: 2020-04-08, release date: 2021-04-21, Last modification date: 2023-11-15) |
Primary citation | Hosseinzadeh, P.,Watson, P.R.,Craven, T.W.,Li, X.,Rettie, S.,Pardo-Avila, F.,Bera, A.K.,Mulligan, V.K.,Lu, P.,Ford, A.S.,Weitzner, B.D.,Stewart, L.J.,Moyer, A.P.,Di Piazza, M.,Whalen, J.G.,Greisen, P.J.,Christianson, D.W.,Baker, D. Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nat Commun, 12:3384-3384, 2021 Cited by PubMed: 34099674DOI: 10.1038/s41467-021-23609-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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