6WFK
Crystal structure of human Naa50 in complex with CoA and an inhibitor (compound 4a) identified using DNA encoded library technology
Summary for 6WFK
Entry DOI | 10.2210/pdb6wfk/pdb |
Related | 6WF3 6WF5 6WFG |
Descriptor | N-alpha-acetyltransferase 50, COENZYME A, (4S)-1-methyl-N-{(3S,5S)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide, ... (4 entities in total) |
Functional Keywords | n-alpha-acetyltransferase 50, inhibitor complex, dna encoded library, coa, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 62674.81 |
Authors | Greasley, S.E.,Feng, J.,Deng, Y.-L.,Stewart, A.E. (deposition date: 2020-04-03, release date: 2020-07-01, Last modification date: 2023-10-18) |
Primary citation | Kung, P.P.,Bingham, P.,Burke, B.J.,Chen, Q.,Cheng, X.,Deng, Y.L.,Dou, D.,Feng, J.,Gallego, G.M.,Gehring, M.R.,Grant, S.K.,Greasley, S.,Harris, A.R.,Maegley, K.A.,Meier, J.,Meng, X.,Montano, J.L.,Morgan, B.A.,Naughton, B.S.,Palde, P.B.,Paul, T.A.,Richardson, P.,Sakata, S.,Shaginian, A.,Sonnenburg, W.K.,Subramanyam, C.,Timofeevski, S.,Wan, J.,Yan, W.,Stewart, A.E. Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library. Acs Med.Chem.Lett., 11:1175-1184, 2020 Cited by PubMed: 32550998DOI: 10.1021/acsmedchemlett.0c00029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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