6WFH

Streptomyces coelicolor methylmalonyl-CoA epimerase substrate complex

6WFH の概要

• エントリーDOI: 10.2210/pdb6wfh/pdb
• 分子名称: Methylmalonyl-CoA epimerase, COBALT (II) ION, (3S,5R,9R,19E)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,19-tetrahydroxy-8,8,20-trimethyl-10,14-dioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphahenicos-19-en-21-oic acid 3,5-dioxide (non-preferred name), ... (7 entities in total)
• 機能のキーワード: epimerase, acid-base, enol, enolate, isomerase
• 由来する生物種: Streptomyces coelicolor
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17330.06

構造登録者

Stunkard, L.M.,Benjamin, A.B.,Bower, J.B.,Huth, T.J.,Lohman, J.R. (登録日: 2020-04-03, 公開日: 2020-07-08, 最終更新日: 2023-10-18)

• 主引用文献: Stunkard, L.M.,Benjamin, A.B.,Bower, J.B.,Huth, T.J.,Lohman, J.R.; Substrate Enolate Intermediate and Mimic Captured in the Active Site of Streptomyces coelicolor Methylmalonyl-CoA Epimerase.; Chembiochem, 23:e202100487-e202100487, 2022; PubMed: 34856049; DOI: 10.1002/cbic.202100487

実験手法

X-RAY DIFFRACTION (1.84 Å)