6WEA

YTH domain of human YTHDC1 with a 10mer Oligo Containing N6mA

6WEA の概要

• エントリーDOI: 10.2210/pdb6wea/pdb
• 分子名称: YTH domain-containing protein 1, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*TP*C)-3'), 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: n6-methyladenine binding protein domain, ssdna, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 89451.95

構造登録者

Horton, J.R.,Cheng, X. (登録日: 2020-04-01, 公開日: 2020-07-15, 最終更新日: 2023-10-18)

• 主引用文献: Woodcock, C.B.,Horton, J.R.,Zhou, J.,Bedford, M.T.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.; Nucleic Acids Res., 48:10329-10341, 2020; PubMed: 32663306; DOI: 10.1093/nar/gkaa604

実験手法

X-RAY DIFFRACTION (1.8 Å)