6WCO
Structure of SARS main protease bound to inhibitor X47
Summary for 6WCO
Entry DOI | 10.2210/pdb6wco/pdb |
Related | 6W79 |
Descriptor | Main protease, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclopentylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide, ... (5 entities in total) |
Functional Keywords | covid-19, sars, sars-cov, main protease, 3c-like protease, 3cl protease, 3clpro, mpro, broad-spectrum, inhibitor, proteinase, non-covalent, reversible, structural genomics, center for structural genomics of infectious diseases, csgid, antiviral protein, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | SARS coronavirus Urbani |
Total number of polymer chains | 1 |
Total formula weight | 34790.80 |
Authors | Mesecar, A.D.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-03-30, release date: 2020-08-05, Last modification date: 2023-10-18) |
Primary citation | Mesecar, A.D. A taxonomically-driven approach to development of potent, broad-spectrum inhibitors of coronavirus main protease including SARS-CoV-2 (COVID-19) To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
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