6WCO

Structure of SARS main protease bound to inhibitor X47

6WCO の概要

• エントリーDOI: 10.2210/pdb6wco/pdb
• 関連するPDBエントリー: 6W79
• 分子名称: Main protease, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclopentylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide, ... (5 entities in total)
• 機能のキーワード: covid-19, sars, sars-cov, main protease, 3c-like protease, 3cl protease, 3clpro, mpro, broad-spectrum, inhibitor, proteinase, non-covalent, reversible, structural genomics, center for structural genomics of infectious diseases, csgid, antiviral protein, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: SARS coronavirus Urbani
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34790.80

構造登録者

Mesecar, A.D.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2020-03-30, 公開日: 2020-08-05, 最終更新日: 2024-12-25)

• 主引用文献: Mesecar, A.D.; A taxonomically-driven approach to development of potent, broad-spectrum inhibitors of coronavirus main protease including SARS-CoV-2 (COVID-19); To Be Published,

実験手法

X-RAY DIFFRACTION (1.48 Å)