6WCK

KRAS G-quadruplex G16T mutant with Bromo Uracil replacing T8 and T16.

Summary for 6WCK

• Entry DOI: 10.2210/pdb6wck/pdb
• Related: 6n65
• Descriptor: DNA (5'-D(*AP*GP*GP*GP*CP*GP*GP*(BRU)P*GP*TP*GP*GP*GP*AP*AP*(BRU)P*AP*GP*GP*GP*AP*A)-3'), POTASSIUM ION (3 entities in total)
• Functional Keywords: kras, g-quadruplex, promoter sequence, g16t mutant, bromouracil, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 14428.00

Authors

Schmidberger, J.W.,Ou, A.,Smith, N.M.,Iyer, K.S.,Bond, C.S. (deposition date: 2020-03-30, release date: 2020-04-15, Last modification date: 2023-10-18)

• Primary citation: Ou, A.,Schmidberger, J.W.,Wilson, K.A.,Evans, C.W.,Hargreaves, J.A.,Grigg, M.,O'Mara, M.L.,Iyer, K.S.,Bond, C.S.,Smith, N.M.; High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A pi-stacking interactions for small-molecule recognition.; Nucleic Acids Res., 48:5766-5776, 2020; PubMed: 32313953; DOI: 10.1093/nar/gkaa262

Experimental method

X-RAY DIFFRACTION (1.801 Å)