6W9I

SUBSTITUTED BENZYLOXYTRICYCLIC COMPOUNDS AS RETINOIC ACID-RELATED ORPHAN RECEPTOR GAMMA T AGONISTS

6W9I の概要

• エントリーDOI: 10.2210/pdb6w9i/pdb
• 分子名称: Nuclear receptor ROR-gamma, Steroid receptor coactivator 1 fusion, 1-(benzyloxy)-4-{1-[(4-fluorophenyl)sulfonyl]cyclopentyl}benzene (3 entities in total)
• 機能のキーワード: rorgt, nuclear hormone receptor, ligand-binding domain, inve agonist, transferase-transferase inhibitor complex, transfe, transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33297.42

構造登録者

Sack, J.S. (登録日: 2020-03-23, 公開日: 2020-04-29, 最終更新日: 2023-10-18)

• 主引用文献: Harikrishnan, L.S.,Gill, P.,Kamau, M.G.,Qin, L.Y.,Ruan, Z.,O'Malley, D.,Huynh, T.,Stachura, S.,Cavallaro, C.L.,Lu, Z.,J-W Duan, J.,Weigelt, C.A.,Sack, J.S.,Ruzanov, M.,Khan, J.,Gururajan, M.,Wong, J.J.,Huang, Y.,Yarde, M.,Li, Z.,Chen, C.,Sun, H.,Borowski, V.,Murtaza, A.,Fink, B.E.; Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (ROR gamma t) agonists.; Bioorg.Med.Chem.Lett., 30:127204-127204, 2020; PubMed: 32334911; DOI: 10.1016/j.bmcl.2020.127204

実験手法

X-RAY DIFFRACTION (1.608 Å)