6W7L

Structure of Tdp1 catalytic domain in complex with inhibitor XZ632p

6W7L の概要

• エントリーDOI: 10.2210/pdb6w7l/pdb
• 分子名称: Tyrosyl-DNA phosphodiesterase 1, 4-[(2-phenylimidazo[1,2-a]pyrazin-3-yl)amino]benzene-1,2-dicarboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: phosphodiesterase, inhibitor, cancer drug target, dna binding protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105249.64

構造登録者

Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R.,Waugh, D.S. (登録日: 2020-03-19, 公開日: 2021-03-24, 最終更新日: 2023-10-18)

• 主引用文献: Zhao, X.Z.,Kiselev, E.,Lountos, G.T.,Wang, W.,Tropea, J.E.,Needle, D.,Hilimire, T.A.,Schneekloth, J.S.,Waugh, D.S.,Pommier, Y.,Burke, T.R.; Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites; Chemical Science, 12:3876-3884, 2021; DOI: 10.1039/D0SC05411A

実験手法

X-RAY DIFFRACTION (1.856 Å)