6W7J
Structure of Tdp1 catalytic domain in complex with inhibitor XZ635p
Summary for 6W7J
Entry DOI | 10.2210/pdb6w7j/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, 4-{[2-(2-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl]amino}benzene-1,2-dicarboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | phosphodiesterase, inhibitor, cancer drug target, dna binding protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 105279.67 |
Authors | Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R.,Waugh, D.S. (deposition date: 2020-03-19, release date: 2021-03-24, Last modification date: 2023-10-18) |
Primary citation | Lountos, G.T.,Waugh, D.S. Tdp1 catalytic domain To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.489 Å) |
Structure validation
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