6W63
Structure of COVID-19 main protease bound to potent broad-spectrum non-covalent inhibitor X77
6W63 の概要
エントリーDOI | 10.2210/pdb6w63/pdb |
分子名称 | 3C-like proteinase, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide (3 entities in total) |
機能のキーワード | covid-19, sars, sars-cov-2, sars-cov, main protease, 3c-like protease, 3cl protease, 3clpro, mpro, broad-spectrum, inhibitor, proteinase, non-covalent, reversible, structural genomics, center for structural genomics of infectious diseases, csgid, antiviral protein, viral protein-inhibitor complex, viral protein/inhibitor |
由来する生物種 | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 34285.13 |
構造登録者 | Mesecar, A.D.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2020-03-16, 公開日: 2020-03-25, 最終更新日: 2023-10-18) |
主引用文献 | Mesecar, A.D. A taxonomically-driven approach to development of potent, broad-spectrum inhibitors of coronavirus main protease including SARS-CoV-2 (COVID-19) To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
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